Single-Cell Transcriptomics & Proteomics Identify Tumor & Microenvironment Niches Leading to Resistance to TKI & ICI in EGFRSensitive Mutant Non-Small Cell Lung Cancer Patients

• Elucidate the complex interplay between tumor, stromal and immune milieu in real-world patients leading to resistance to TKI and ICI using single cell spatial tumor genomic expression and TME proteomics
• Identify cold tumor regions as core spatial niches of TKI and ICI resistance, where tumor cells exhibit upregulated expression of AREG, MUC1, MET, ACE2, and ASCL1, driving tumor proliferation and immune evasion
• Pave the way for AI-enabled discovery of novel predictive biomarkers and targeted therapeutic strategies to overcome TKI and ICI resistance 

Speakers:

Jean Lopategui

Professor, Pathology

Cedars-Sinai Medical Center